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Microtissue & organoid engineering
Microwell platforms for generating arrays of uniform cartilage microtissues, tumour spheroids and humanised bone marrow micro-ossicles at scale.
Postdoctoral Research Fellow
Dr Md Shafiullah Shajib
Manufacture and cryopreservation of cartilage microtissues and tumour spheroids as standardised, assay-ready three-dimensional tissues.
School of Biomedical Sciences, The University of Queensland · Brisbane, Queensland, Australia
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Citations
282 since 2021
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h-index
11 since 2021
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i10-index
11 since 2021
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Publications
journal articles and thesis
About
Translational research from bench chemistry to engineered tissue
Biomedical scientist working at the intersection of tissue engineering, stem cell biology and pharmacology. My work develops manufacturing and cryopreservation processes for cartilage microtissues and tumour spheroids — off-the-shelf, highly reproducible 3D tissues ready for regenerative therapy research and drug screening. Earlier training in natural product chemistry and behavioural pharmacology underpins a translational approach spanning bench chemistry to preclinical models.
Areas of expertise
- Tissue engineering
- Cell therapy
- Organoids & spheroids
- Cryopreservation
- Mesenchymal stromal cells
- Chondrogenesis
- Drug screening assays
- Behavioural pharmacology
- Pain & antinociception
- Natural product chemistry
- GC-MS / phytochemistry
- Toxicology
Research focus
Making three-dimensional tissues reproducible
02
Cryopreservation science
Processes that freeze and revive 3D tissues without loss of phenotype, yielding ready-to-use products for direct deployment in assays and therapy pipelines.
03
Cartilage repair & chondrogenesis
How TGF-β1, BMP-2 and GDF-5 signalling steers bone-marrow stromal cell fate, and how collagen network damage limits cartilage tissue integration.
04
Pharmacology & natural products
Antinociceptive, neuropharmacological and antioxidant characterisation of plant-derived compounds, including isolation of polymethoxyflavones and catechin.
Publications
Selected peer-reviewed work
2023Journal of the Royal Society Interface5 citations
A tumour-spheroid manufacturing and cryopreservation process that yields a highly reproducible product ready for direct use in drug screening assays
Shajib MS, Futrega K, Davies AM, Franco RAG, McKenna E, Guillesser B, Klein TJ, Crawford RW, Doran MR
doi:10.1098/rsif.2023.0468
2023Journal of Tissue Engineering13 citations
Method for manufacture and cryopreservation of cartilage microtissues
Shajib MS, Futrega K, Franco RAG, McKenna E, Guillesser B, Klein TJ, Crawford RW, Doran MR
doi:10.1177/20417314231176901
2022Journal of Tissue Engineering23 citations
Collagenase treatment appears to improve cartilage tissue integration but damage to collagen networks is likely permanent
Shajib MS, Futrega K, Klein TJ, Crawford RW, Doran MR
doi:10.1177/20417314221074207
2018Frontiers in Pharmacology37 citations
Polymethoxyflavones from Nicotiana plumbaginifolia (Solanaceae) exert antinociceptive and neuropharmacological effects in mice
Shajib MS, Rashid RB, Ming LC, Islam S, Sarker MMR, Nahar L, Sarker SD, Datta BK, Rashid MA
doi:10.3389/fphar.2018.00085
2015Frontiers in Pharmacology50 citations
Antinociceptive and neuropharmacological activities of methanol extract of Phoenix sylvestris fruit pulp
Shajib MS, Akter S, Ahmed T, Imam MZ
doi:10.3389/fphar.2015.00212
Further publications
- 2018In vitro antioxidant, antimicrobial, membrane stabilization and thrombolytic activities of Dioscorea hispida Dennst.Miah MM, Das P, Ibrahim Y, Shajib MS, Rashid MA · European Journal of Integrative Medicine
- 2023Microtissue culture provides clarity on the relative chondrogenic and hypertrophic response of bone-marrow-derived stromal cells to TGF-β1, BMP-2, and GDF-5Franco RAG, McKenna E, Shajib MS, Guillesser B, Robey PG, Crawford RW, Doran MR, Futrega K · Cells
- 2023A microwell device for the efficient generation of arrays of microtissues and humanized bone marrow micro-ossiclesFutrega K, Shajib MS, Robey PG, Doran MR · Organoids
- 2023GC-MS analysis and pharmacological evaluations of Phoenix sylvestris (Roxb.) seeds provide new insights into the management of oxidative stress and hyperglycemiaShajib MS, Islam S, Alam S, Rashid RB, Afroze M, Khan M, Datta BK, Nahar L, Sarker SD, Rashid MA · Food Science & Nutrition
- 2022Inhibition of BMP signaling with LDN 193189 can influence bone marrow stromal cell fate but does not prevent hypertrophy during chondrogenesisFranco RAG, McKenna E, Robey PG, Shajib MS, Crawford RW, Doran MR, Futrega K · Stem Cell Reports
- 2019Antinociceptive activities of Artocarpus lacucha Buch-ham (Moraceae) and its isolated phenolic compound, catechin, in miceIslam S, Shajib MS, Rashid RB, Khan MF, Al-Mansur M, Datta BK, Rashid MA · BMC Complementary and Alternative Medicine
- 2016Antinociceptive effect of methanol extract of Celosia cristata Linn. in miceIslam S, Shajib MS, Ahmed T · BMC Complementary and Alternative Medicine
- 2017Highly oxygenated flavonoids from the leaves of Nicotiana plumbaginifolia (Solanaceae)Shajib MS, Datta BK, Sohrab MH, Rashid MA, Nahar L, Sarker SD · Records of Natural Products
- 2018Neuropharmacological activities of methanol extract of Albizia lebbeck (L.) BenthIslam S, Shajib MS, Datta BK, Rashid MA · Bangladesh Pharmaceutical Journal
- 2018A review on anti-diabetic plantsQais N, Jahan S, Shajib MS · Dhaka University Journal of Pharmaceutical Sciences
- 2019Total phenolic content, membrane stabilization and thrombolytic activities of Corypha taliera (Arecaceae) flowersChowdhury A, Shajib MS, Tahia F, Alam MA, Rashid MA · Dhaka University Journal of Pharmaceutical Sciences
- 2019Isolation of zizyberenalic acid and biological studies of Ziziphus mauritiana Lam. growing in BangladeshKarim MA, Hossain MK, Al-Mansur MA, Shajib MS, Rashid MA · Bangladesh Journal of Botany
- 2018Chemical constituents and protection of biodiversity of Corypha taliera Roxb., a critically endangered plant of BangladeshChowdhury A, Alam MA, Shajib MS, Al-Mansur MA, Rashid MA · Bangladesh Pharmaceutical Journal
- 2018Preliminary phytochemical and pharmacological screenings of Plumbago indica L. and Alpinia conchigera GriffIbrahim M, Hossain MA, Shajib MS, Rashid MA · Dhaka University Journal of Pharmaceutical Sciences
- 2017Effect of ayurvedic preparation Mrityunjay in digoxin-induced arrhythmic ratsRefaya R, Sharmin Z, Shajib MS, Chowdhury JA, Chowdhury AA, Kabir S, Rashid MA, Amran MS · African Journal of Pharmacy and Pharmacology
- 2023Cryopreservation and utility of cancer organoids and cartilage microtissuesShajib MS · PhD thesis, Queensland University of Technology
Background
Training and appointments
Present
Postdoctoral Research Fellow
School of Biomedical Sciences, The University of Queensland
Research on engineered microtissues and cell-based models; available for HDR student supervision.
2022 –
Scientist, Toxicology
Agilex Biolabs, Brisbane
Preclinical toxicology laboratory appointment, as recorded on ORCID.
2023
PhD, Biomedical Sciences
Queensland University of Technology
Thesis: Cryopreservation and utility of cancer organoids and cartilage microtissues. Supervised by Michael Doran, Ross Crawford and Travis Klein.
2019 – 2022
Animal Technician, Toxicology
TetraQ, Brisbane
Preclinical toxicology support during doctoral training.
2021 – 2022
Sessional Academic
School of Biomedical Sciences, Queensland University of Technology
Teaching assistant in biomedical sciences.
2016 – 2018
Research Assistant, then Associate Researcher
Molecular Pharmacology and Herbal Drug Research Laboratory, University of Dhaka
Isolation and preclinical evaluation of plant-derived compounds for pain, neuropharmacology and metabolic disease.
2015 – 2016
Research Student
Pharmaceutical Sciences Division, BCSIR
Natural-products research training in Dhaka.
2014 / 2016
BPharm and MPharm
Stamford University Bangladesh
Undergraduate and master’s training in pharmacy.
Contact
Collaboration and supervision enquiries
Currently available to supervise higher-degree research students and open to collaborations in tissue engineering, cell therapy and preclinical pharmacology.
- m.shajib@uq.edu.au
- Phone
- +61 7 344 34927
- Based in
- Brisbane, Queensland, Australia